Term: unclassified variant

Pronunciation: (un-KLA-sih-fide VAYR-ee-unt)

Description:

A change in a gene’s DNA sequence that has an unknown effect on a person’s health. There is usually not enough information about an unclassified variant to know whether it increases a person’s risk of developing a disease, such as cancer. Also called variant of uncertain significance, variant of unknown significance, and VUS.